Mansfield boss Peter Shirtliff can welcome back Richie Barker, Stephen Dawson, Jake Buxton, Alex John-Baptiste and Gareth Jelleyman.
Simon Brown (knee) and Jon-Olav Hjelde (knee) as the only absentees.
Andy Cole is set for his Portsmouth first-team debut and other new signings Niko Kranjcar, Rodolph Douala and Manuel Fernandes are also set to play.
Keeper Dean Kiely will replace David James, while Sol Campbell, Pedro Mendes and Kanu will be rested.
Portsmouth (from): Kiely, Pamarot, O'Brien, Duffy, Fordyce, Wilson, Hughes, Douala, Koroman, Cole, LuaLua, Thompson, Fernandes, Kranjcar, Songo'o, Taylor, O'Neil, Davis, Ashdown
1900-10-80-70
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